Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28805406 | 0.86 | KDM4E (0.41) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL21957936 | 0.84 | KDM4E (0.55) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL1503284 | 0.83 | KDM4E (0.62) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL22653038 | 0.81 | KDM4E (0.64) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL4477892 | 0.81 | KDM4E (0.55) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL14358101 | 0.80 | KDM4E (0.66) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL353589 | 0.79 | KDM4E (0.70) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| Benzene SCHEMBL11818131 | 0.79 | KDM4E (0.70) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL9295028 | 0.79 | KDM4E (0.60) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 | |
| SCHEMBL29852763 | 0.78 | KDM4E (0.48) | KDM4EMAPTCYP1A2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157085-A1 | MODULATORS OF HEMOGLOBIN | HBG1, HBG2, HBB | KDM4E 1774/4885MAPT 4092/4885CYP1A2 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.