SCHEMBL22019317

SCHEMBL22019317

CS(=O)(=O)c1cccc(C(=O)c2cnc(N3CCCCC3c3ccccc3)s2)c1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CPT2 P23786 1/20 0.39
CPT1A P50416 1/20 0.39
NR1H2 P55055 15/20 0.39
NR1H3 Q13133 12/20 0.39
CNR2 P34972 1/20 0.38
MLYCD O95822 1/20 0.37
LMNA P02545 1/20 0.37
TSHR P16473 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21962690 1.00 CPT2 (0.39) CPT2CPT1ANR1H2NR1H3CNR2
SCHEMBL22019320 0.97 NR1H2 (0.39) NR1H2NR1H3MLYCD
SCHEMBL21962682 0.97 NR1H2 (0.39) NR1H2NR1H3MLYCD
SCHEMBL22020535 0.89 VNN1 (0.44) NR1H2NR1H3MLYCD
SCHEMBL21962341 0.89 VNN1 (0.44) NR1H2NR1H3MLYCD
SCHEMBL22019319 0.89 VNN1 (0.42) LMNATSHR
SCHEMBL21962626 0.89 VNN1 (0.42) LMNATSHR
SCHEMBL21962518 0.86 NR1H2 (0.42) NR1H2NR1H3
SCHEMBL22019162 0.86 NR1H2 (0.42) NR1H2NR1H3
SCHEMBL21962448 0.86 KRAS (0.41) MLYCDLMNATSHRHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020102575-A1 HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF INCEPTION IBD, INC. (US) 2020-05-22 WO disclosed