Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203862 | 0.81 | EGLN1 (0.74) | EGLN1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2204239 | 0.81 | EGLN1 (0.83) | EGLN1ALDH1A1 | |
| SCHEMBL2200760 | 0.80 | EGLN1 (1.00) | EGLN1ALDH1A1 | |
| SCHEMBL15327067 | 0.79 | KDM4E (0.59) | KDM4EPOLBGAAPSMD14ALDH1A1 | |
| SCHEMBL2202703 | 0.78 | EGLN1 (0.66) | EGLN1KDM4EPSMD14ALDH1A1HPGD | |
| SCHEMBL2201303 | 0.78 | EGLN1 (0.62) | EGLN1ALDH1A1 | |
| SCHEMBL2206161 | 0.78 | EGLN1 (0.73) | EGLN1KDM4EALDH1A1 | |
| SCHEMBL12907922 | 0.77 | KDM4E (0.70) | KDM4EPOLBPSMD14ALDH1A1HPGD | |
| SCHEMBL1722407 | 0.77 | KDM4E (0.70) | KDM4EPOLBGAAPSMD14ALDH1A1 | |
| SCHEMBL27815171 | 0.77 | KDM4E (0.70) | KDM4EPOLBPSMD14ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105168213-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA | 2015-12-23 | — | — | CN | claimed |
| US-8969380-B2 | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA (LU) | 2015-03-03 | — | — | US | claimed |
| EP-2519503-B1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM SA (LU) | 2013-10-23 | — | — | EP | claimed |
| US-20120329797-A1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM SA (LU) | 2012-12-27 | — | — | US | claimed |
| EP-2519503-A1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM S.A. (LU) | 2012-11-07 | — | — | EP | claimed |
| CN-102712597-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives as antifungal agents | POLICHEM SA | 2012-10-03 | — | — | CN | claimed |
| EP-2345642-A1 | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | claimed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | claimed |
| EP-0927164-A1 | 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1999-07-07 | — | — | EP | claimed |
| WO-1998011073-A1 | 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-03-19 | — | — | WO | claimed |
| CN-105168213-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA | 2015-12-23 | — | — | CN | disclosed |
| US-8969380-B2 | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA (LU) | 2015-03-03 | — | — | US | disclosed |
| US-8969380-B2 | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA (LU) | 2015-03-03 | — | — | US | disclosed |
| EP-2519503-B1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM SA (LU) | 2013-10-23 | — | — | EP | disclosed |
| WO-2011080265-A1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011080265-A1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| US-6211376-B1 | HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS | PHARMACIA & UPJOHN COMPANY | 2001-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329797-A1 | SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS | ERG28, TUBA8, CYP51A1 | EGLN1 1246/4885KDM4E 3065/4885POLB 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.