Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 5/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019706 | 0.94 | KDM4E (0.38) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL22021184 | 0.84 | ACHE (0.48) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL30162424 | 0.84 | ACHE (0.48) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL24871633 | 0.82 | KDM4E (0.33) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL24978542 | 0.82 | CRHR1 (0.33) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL22020067 | 0.80 | KDM4E (0.36) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL30120755 | 0.79 | ACHE (0.50) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL22010279 | 0.79 | ACHE (0.50) | KDM4EHRH2HRH3ACHEMEN1 | |
| SCHEMBL24871951 | 0.76 | KDM4E (0.33) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL24871638 | 0.76 | KDM4E (0.33) | KDM4EACHEMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |