Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22021534 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22010514 | 0.84 | ACHE (0.50) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL30162576 | 0.84 | ACHE (0.50) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22020718 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL24977966 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22020719 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL24977994 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22020099 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22019782 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 | |
| SCHEMBL22019783 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1KDM4EACHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |