Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24977994 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL21963150 | 0.83 | ACHE (0.46) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL22019708 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL22019780 | 0.78 | KMT2A (0.36) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL22020718 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL22020720 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL22010514 | 0.73 | ACHE (0.50) | SMN1; SMN2L3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL30162576 | 0.73 | ACHE (0.50) | SMN1; SMN2L3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL22019783 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1KDM4EHSD17B10TSHR | |
| SCHEMBL24978509 | 0.73 | LMNA (0.48) | SMN1; SMN2KDM4EHSD17B10TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |