Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22282198 | 0.86 | HRH3 (0.38) | HRH2HRH3 | |
| SCHEMBL21963095 | 0.84 | HRH3 (0.44) | HRH2HRH3PDE10A | |
| SCHEMBL31475643 | 0.84 | HRH3 (0.44) | HRH2HRH3PDE10A | |
| SCHEMBL24977997 | 0.81 | HRH2 (0.36) | HRH2HRH3 | |
| SCHEMBL24978154 | 0.75 | HRH2 (0.40) | HRH2HRH3 | |
| SCHEMBL21963378 | 0.72 | HRH3 (0.43) | HRH2HRH3 | |
| SCHEMBL24978304 | 0.71 | HRH3 (0.44) | HRH2HRH3 | |
| SCHEMBL22019718 | 0.70 | HRH3 (0.38) | HRH2HRH3 | |
| SCHEMBL22020826 | 0.70 | HRH3 (0.38) | HRH2HRH3 | |
| SCHEMBL22021272 | 0.70 | HRH3 (0.38) | HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |