Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.38 |
| ▸ | HRH2 | P25021 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020826 | 1.00 | HRH3 (0.38) | HRH3HRH2KDM4ENLRP3ACHE | |
| SCHEMBL22021272 | 1.00 | HRH3 (0.38) | HRH3HRH2KDM4ENLRP3ACHE | |
| SCHEMBL22282198 | 0.82 | HRH3 (0.38) | HRH3HRH2 | |
| SCHEMBL24979122 | 0.81 | ACHE (0.55) | HRH3HRH2KDM4EACHEMEN1 | |
| SCHEMBL30120762 | 0.81 | ACHE (0.55) | HRH3HRH2KDM4EACHEMEN1 | |
| SCHEMBL21962929 | 0.81 | ACHE (0.55) | HRH3HRH2KDM4EACHEMEN1 | |
| SCHEMBL21962895 | 0.81 | ACHE (0.55) | HRH3HRH2KDM4EACHEMEN1 | |
| SCHEMBL30162092 | 0.81 | ACHE (0.55) | HRH3HRH2KDM4EACHEMEN1 | |
| SCHEMBL24977969 | 0.78 | NLRP3 (0.38) | HRH3HRH2KDM4ENLRP3ACHE | |
| SCHEMBL24978209 | 0.78 | HRH3 (0.36) | HRH3HRH2KDM4ENLRP3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |