Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020067 | 0.84 | KDM4E (0.36) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL22020326 | 0.82 | ACHE (0.50) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL30162458 | 0.82 | ACHE (0.50) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL22019778 | 0.80 | MEN1 (0.37) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL24977963 | 0.80 | KDM4E (0.35) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL22019756 | 0.80 | KDM4E (0.35) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL22019783 | 0.78 | SMN1; SMN2 (0.40) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL22019706 | 0.76 | KDM4E (0.38) | KDM4EACHEMEN1MAPK1KMT2A | |
| SCHEMBL21963067 | 0.75 | GAA (0.46) | KDM4EACHEMEN1KMT2AEEF2K | |
| SCHEMBL19272311 | 0.73 | ACHE (0.54) | KDM4EACHEMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |