Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24978158 | 0.87 | GAA (0.38) | KDM4EGAACYP1A2POLBTSHR | |
| SCHEMBL24979083 | 0.83 | ACHE (0.46) | KDM4ECYP1A2TSHRMAPK1ALDH1A1 | |
| SCHEMBL30162178 | 0.83 | ACHE (0.46) | KDM4ECYP1A2TSHRMAPK1ALDH1A1 | |
| SCHEMBL22019706 | 0.81 | KDM4E (0.38) | KDM4ECYP1A2MAPK1ALDH1A1NPC1 | |
| SCHEMBL22019725 | 0.81 | CYP1A2 (0.33) | KDM4EGAACYP1A2POLBTSHR | |
| SCHEMBL22020006 | 0.80 | TSHR (0.34) | KDM4EGAACYP1A2POLBTSHR | |
| SCHEMBL24977971 | 0.80 | CYP1A2 (0.31) | KDM4EGAACYP1A2POLBTSHR | |
| SCHEMBL22020067 | 0.78 | KDM4E (0.36) | KDM4ECYP1A2MAPK1ALDH1A1ACHE | |
| SCHEMBL22019707 | 0.76 | KDM4E (0.37) | KDM4EGAACYP1A2MAPK1ALDH1A1 | |
| SCHEMBL22019959 | 0.74 | NPSR1 (0.36) | KDM4ETSHRMAPK1CRHR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |