SCHEMBL2202057

SCHEMBL2202057

C#Cc1c(C)ccc2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.54
CYP1A2 P05177 6/20 0.54
TSHR P16473 5/20 0.54
ALDH1A1 P00352 6/20 0.46
HSD17B10 Q99714 5/20 0.44
TDP1 Q9NUW8 2/20 0.44
HPGD P15428 3/20 0.41
HPRT1 P00492 1/20 0.41
HIF1A Q16665 2/20 0.39
CYP3A4 P08684 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
MAPK1 P28482 1/20 0.39
CASP1 P29466 1/20 0.39
RAB9A P51151 1/20 0.39
CASP7 P55210 1/20 0.39
ATM Q13315 1/20 0.39
CYP1B1 Q16678 1/20 0.38
LCK P06239 1/20 0.38
FYN P06241 1/20 0.38
ADORA3 P0DMS8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31610241 0.85 TSHR (0.42) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL3249045 0.79 CYP1A2 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL5251870 0.79 CYP1A2 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL5431973 0.77 CYP2A6 (0.46) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL31676618 0.77 CYP2A6 (0.46) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL23054105 0.75 CYP2A6 (0.44) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL688993 0.75 ALDH1A1 (0.46) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL20529660 0.75 PTPN22 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL21160351 0.75 CYP2A6 (0.44) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL30220310 0.75 CYP2A6 (0.44) CYP2A6CYP1A2TSHRALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113493454-B Quinolizine aza double aromatic ring axial chiral compound and its synthesis method 南京理工大学 2022-05-27 CN disclosed
CN-113493454-A Quinolizine aza double aromatic ring axial chiral compound and its synthesis method 南京理工大学 2021-10-12 CN disclosed
EP-1964861-B1 ACETYLENE-BASED POLYMER NAT INST OF ADVANCED IND SCIEN (JP) 2012-10-17 EP disclosed
US-7977441-B2 Acetylene-based polymer NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2011-07-12 US disclosed
US-7777218-B1 Memory cell containing copolymer containing diarylacetylene portion SPANSION LLC (US) 2010-08-17 US disclosed
US-7715083-B2 Light control material and light control film SEKISUI CHEMICAL CO., LTD. (JP) 2010-05-11 US disclosed
US-20090253872-A1 Acetylene-Based Polymer NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2009-10-08 US disclosed
US-20090080056-A1 Light Control Material and Light Control Film SEKISUI CHEMICAL CO., LTD (JP) 2009-03-26 US disclosed
EP-1964861-A1 ACETYLENE POLYMER National Institute of Advanced Industrial Science and Technology (JP) 2008-09-03 EP disclosed
EP-1953575-A1 LIGHT CONTROL MATERIAL AND LIGHT CONTROL FILM Sekisui Chemical Co., Ltd. (JP) 2008-08-06 EP disclosed
US-7105374-B1 Memory cell containing copolymer containing diarylacetylene portion SPANSION LLC (US) 2006-09-12 US disclosed