Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 3/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459024 | 0.86 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDTSHRHSD17B10 | |
| SCHEMBL18416896 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL20305437 | 0.80 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL20449762 | 0.80 | NQO2 (0.45) | ALDH1A1SMN1; SMN2HPGDTSHRMAPT | |
| SCHEMBL6127934 | 0.80 | PDPK1 (0.33) | PKM | |
| SCHEMBL25647663 | 0.76 | TAAR1 (0.33) | LMNATSHRMAPTNQO2NPC1 | |
| SCHEMBL12566319 | 0.75 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL18459023 | 0.74 | ATP4A (0.35) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL25079344 | 0.73 | HTT (0.43) | LMNASMN1; SMN2MAPTNPC1PKM | |
| SCHEMBL18876097 | 0.73 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2MAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981886-B2 | Antibiotics derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-07-19 | — | — | US | disclosed |
| EP-1888574-B1 | NEW ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | EP | disclosed |
| US-20080280888-A1 | Antibiotics Derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-11-13 | — | — | US | disclosed |
| EP-1888574-A2 | NEW ANTIBIOTIC DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126171-A2 | NEW ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280888-A1 | Antibiotics Derivatives | NR4A1, NR2C2, NR4A3 | ALDH1A1 3969/4885LMNA 2688/4885SMN1; SMN2 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.