Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.62 |
| ▸ | ACACB | O00763 | 4/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 9/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11819804 | 0.86 | HRH3 (0.68) | HRH3ACACBCARM1 | |
| SCHEMBL23841485 | 0.83 | HRH3 (0.58) | HRH3ACACBCARM1 | |
| SCHEMBL11830371 | 0.81 | HRH3 (0.62) | HRH3ACACB | |
| SCHEMBL21216139 | 0.79 | HRH3 (0.54) | HRH3ACACBCARM1 | |
| SCHEMBL21216216 | 0.78 | HRH3 (0.58) | HRH3ACACBCARM1 | |
| SCHEMBL5097371 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL23482175 | 0.76 | HRH3 (0.49) | HRH3ACACBCARM1 | |
| SCHEMBL17341955 | 0.75 | RXRA (0.49) | — | |
| SCHEMBL2608857 | 0.75 | RXRA (0.49) | PRMT5 | |
| SCHEMBL11742426 | 0.74 | HRH3 (0.64) | HRH3ACACBCARM1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | PFIZER INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | DPYD, PDXK, TYMP | HRH3 2448/4885ACACB 3359/4885CARM1 4273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.