Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17707649 | 0.97 | AKR1C3 (0.50) | AKR1C3HDAC6HDAC1CYP2C9DRD2 | |
| SCHEMBL2201766 | 0.88 | FAAH (0.41) | AKR1C3HDAC6HDAC1CYP2C9DRD2 | |
| SCHEMBL4775033 | 0.88 | FAAH (0.41) | AKR1C3HDAC6HDAC1CYP2C9DRD2 | |
| Trifluoroacetic Acid SCHEMBL17707673 | 0.88 | HDAC6 (0.46) | AKR1C3HDAC6HDAC1CYP2C9HDAC4 | |
| Trifluoroacetic Acid SCHEMBL4776699 | 0.88 | HDAC6 (0.46) | AKR1C3HDAC6HDAC1CYP2C9HDAC4 | |
| SCHEMBL17707612 | 0.86 | SLC6A7 (0.44) | AKR1C3HDAC6HDAC1CYP2C9HDAC4 | |
| SCHEMBL17707587 | 0.84 | HDAC6 (0.48) | AKR1C3HDAC6HDAC1CYP2C9HDAC4 | |
| Trifluoroacetic Acid SCHEMBL2202774 | 0.83 | CCR1 (0.40) | HDAC6HDAC1CYP2C9HDAC4HDAC3 | |
| Trifluoroacetic Acid SCHEMBL4778412 | 0.83 | CCR1 (0.40) | HDAC6HDAC1CYP2C9HDAC4HDAC3 | |
| Trifluoroacetic Acid SCHEMBL2204116 | 0.81 | HDAC6 (0.43) | HDAC6HDAC1CYP2C9HDAC4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | claimed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-7977374-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-07-12 | — | — | US | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | AKR1C3 1729/4885HDAC6 6/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.