Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197914 | 0.84 | MEN1 (0.41) | ALDH1A1KDM4EUSP2SMN1; SMN2MEN1 | |
| SCHEMBL2195582 | 0.84 | GSK3B (0.45) | USP5POLBL3MBTL1 | |
| SCHEMBL2195396 | 0.82 | USP5 (0.38) | ALDH1A1USP5MAPTPOLBAGTR1 | |
| SCHEMBL2197629 | 0.81 | KDM4E (0.43) | ALDH1A1KDM4EMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL2198695 | 0.80 | MAPT (0.39) | ALDH1A1MAPTOPRD1SMN1; SMN2HPGD | |
| SCHEMBL2195384 | 0.78 | RIPK1 (0.37) | KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2196410 | 0.78 | RIPK1 (0.37) | KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL1448846 | 0.77 | ESR1 (0.42) | ALDH1A1MAPTSLC6A2SLC6A3 | |
| SCHEMBL2429212 | 0.77 | ESR1 (0.42) | ALDH1A1MAPTSLC6A2SLC6A3 | |
| SCHEMBL3550509 | 0.76 | L3MBTL1 (0.40) | ALDH1A1KDM4EOPRD1HPGDMLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2116543-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVE AS PLK1 INHIBITOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | disclosed |