Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 6/20 | 0.43 |
| ▸ | TDO2 | P48775 | 6/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202303 | 1.00 | HTR2A (0.44) | HTR2AIDO1TDO2CHRM3POLB | |
| SCHEMBL15575979 | 0.81 | IDO1 (0.43) | IDO1TDO2POLBIRAK4 | |
| SCHEMBL10839238 | 0.79 | IDO1 (0.44) | IDO1TDO2IRAK4 | |
| SCHEMBL10906269 | 0.78 | CHRNB4 (0.59) | — | |
| SCHEMBL10906268 | 0.78 | CHRNB4 (0.59) | — | |
| SCHEMBL3329262 | 0.77 | LTA4H (0.52) | POLBIRAK4 | |
| SCHEMBL1116569 | 0.77 | LTA4H (0.52) | POLBIRAK4 | |
| SCHEMBL1116568 | 0.77 | LTA4H (0.52) | POLBIRAK4 | |
| SCHEMBL1776409 | 0.74 | DDB1 (0.46) | IRAK4 | |
| SCHEMBL27717307 | 0.74 | DDB1 (0.46) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20100160352-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
| EP-1912994-A1 | ADENINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017069-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | HSP90AA1, TRAP1, HSP90AB1 | HTR2A 2398/4885IDO1 2708/4885TDO2 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.