Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19923162 | 0.74 | HTR1A (0.42) | HPGDHTR1ADRD2DRD4 | |
| SCHEMBL19439103 | 0.73 | HPGD (0.77) | HPGDSMN1; SMN2ADORA2AADORA1ADORA3 | |
| SCHEMBL20917431 | 0.71 | HPGD (0.72) | HPGDSMN1; SMN2ADORA2AADORA1ADORA3 | |
| SCHEMBL25676456 | 0.70 | HPGD (0.70) | HPGDSMN1; SMN2ADORA2AADORA1ADORA3 | |
| SCHEMBL10068141 | 0.70 | HPGD (0.70) | HPGDSMN1; SMN2ADORA2AADORA1ADORA3 | |
| SCHEMBL10083505 | 0.70 | HPGD (0.70) | HPGDSMN1; SMN2ADORA2AADORA1ADORA3 | |
| SCHEMBL6980242 | 0.69 | ALDH1A1 (0.38) | SMN1; SMN2 | |
| SCHEMBL28561616 | 0.69 | KMT2A (0.40) | SMN1; SMN2HTR1ADRD2DRD4 | |
| SCHEMBL4346655 | 0.69 | CHRNA7 (0.38) | HTR1ADRD2DRD4 | |
| SCHEMBL19923108 | 0.67 | CCNT1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663285-B1 | FORMYLPYRIDINE DERIVATIVE HAVING FGFR4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2024-01-24 | — | — | EP | disclosed |
| US-11312701-B2 | Formylpyridine derivative having FGFR4 inhibitory activity, preparation method therefor and use thereof | ABBISKO THERAPEUTICS CO., LTD (CN) | 2022-04-26 | — | — | US | disclosed |
| US-20210130323-A1 | FORMYLPYRIDINE DERIVATIVE HAVING FGFR4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2021-05-06 | — | — | US | disclosed |
| CN-110691775-B | Aldehyde pyridine derivative with FGFR4 inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2021-04-23 | — | — | CN | disclosed |
| EP-3663285-A1 | FORMYLPYRIDINE DERIVATIVE HAVING FGFR4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-06-10 | — | — | EP | disclosed |
| CN-110691775-A | Aldehyde pyridine derivative with FGFR4 inhibitory activity, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-01-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312701-B2 | Formylpyridine derivative having FGFR4 inhibitory activity, preparation method therefor and use thereof | FGFR4, FGFR1, FGFR2 | HPGD 967/4885SMN1; SMN2 1020/4885ADORA2A 4050/4885 |
| US-20210130323-A1 | FORMYLPYRIDINE DERIVATIVE HAVING FGFR4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | FGFR4, FGFR1, FGFR2 | HPGD 967/4885SMN1; SMN2 1020/4885ADORA2A 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.