Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 5/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22023299 | 0.83 | KCNH3 (0.44) | CCNT1CDK9GRM4EGLN2 | |
| SCHEMBL22023245 | 0.75 | BACE1 (0.43) | GRM4EGLN2 | |
| SCHEMBL10994631 | 0.74 | CCNT1 (0.49) | CCNT1CDK9CLK1CLK2CLK3 | |
| SCHEMBL29596566 | 0.72 | FGFR4 (0.46) | CCNT1CLK1CLK2CLK3DYRK1A | |
| SCHEMBL22079446 | 0.72 | FGFR4 (0.46) | CCNT1CLK1CLK2CLK3DYRK1A | |
| SCHEMBL22699596 | 0.71 | EPHX1 (0.45) | CCNT1CDK9CLK1CLK2CLK3 | |
| SCHEMBL22680868 | 0.71 | CNR2 (0.41) | CCNT1CDK9CLK1CLK2CLK3 | |
| Hydrochloric Acid SCHEMBL9388001 | 0.69 | CCNT1 (0.39) | CCNT1CDK9CLK1CLK2CLK3 | |
| SCHEMBL1225735 | 0.69 | MCHR1 (0.36) | CCNT1CDK9CLK1CLK2CLK3 | |
| SCHEMBL1225969 | 0.69 | MCHR1 (0.36) | CCNT1CDK9CLK1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663285-A1 | FORMYLPYRIDINE DERIVATIVE HAVING FGFR4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-06-10 | — | — | EP | disclosed |