Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030430 | 0.89 | MAPT (0.55) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| Hydrochloric Acid SCHEMBL5252883 | 0.88 | MAPT (0.53) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL2205198 | 0.87 | CHRM3 (0.51) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL2201632 | 0.82 | KDM4E (0.43) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL17596757 | 0.80 | CYP3A4 (0.47) | LMNACYP3A4TDP1PLOD2PLOD3 | |
| SCHEMBL2202450 | 0.77 | KMT2A (0.55) | CHRM3CHRM2CHRM1CYP2D6MAPT | |
| SCHEMBL9989231 | 0.77 | CHRM3 (0.42) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL17439469 | 0.76 | KMT2A (0.46) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL9295790 | 0.75 | CHRM3 (0.59) | CHRM3KCNH2CHRM2CHRM1CYP2D6 | |
| SCHEMBL28232039 | 0.75 | KDM4E (0.42) | CHRM3KCNH2CHRM2CHRM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | CHRM3 1829/4885KCNH2 4513/4885CHRM2 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.