Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.85 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.85 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.59 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.56 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22029456 | 1.00 | ITGAV (0.85) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22029457 | 1.00 | ITGAV (0.85) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22074099 | 0.94 | ITGAV (0.78) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22029438 | 0.94 | ITGAV (0.78) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22073480 | 0.94 | ITGAV (0.78) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22073497 | 0.93 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22075868 | 0.93 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL24362786 | 0.92 | ITGAV (0.78) | ITGAVITGB3ITGB6 | |
| SCHEMBL22073500 | 0.92 | ITGAV (0.73) | ITGAVITGB3ITGB6ITGB1ITGA4 | |
| SCHEMBL22074614 | 0.92 | ITGAV (0.72) | ITGAVITGB3ITGB6ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481814-B1 | TETRAHYDRONAPHTHYRIDINEPENTANAMIDE INTEGRIN ANTAGONISTS | UNIV ROCKEFELLER (US) | 2022-04-27 | — | — | EP | disclosed |
| US-11192889-B2 | Tetrahydronaphthyridinepentanamide integrin antagonists | THE ROCKEFELLER UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-11192889-B2 | Tetrahydronaphthyridinepentanamide integrin antagonists | THE ROCKEFELLER UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200181138-A1 | TETRAHYDRONAPHTHYRIDINEPENTANAMIDE INTEGRIN ANTAGONISTS | THE ROCKEFELLER UNIVERSITY (US) | 2020-06-11 | — | — | US | disclosed |
| US-20200181138-A1 | TETRAHYDRONAPHTHYRIDINEPENTANAMIDE INTEGRIN ANTAGONISTS | THE ROCKEFELLER UNIVERSITY (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181138-A1 | TETRAHYDRONAPHTHYRIDINEPENTANAMIDE INTEGRIN ANTAGONISTS | ITGAV, ITGB3, ITGA4 | ITGAV 1/4885ITGB3 2/4885ITGB6 21/4885 |
| US-11192889-B2 | Tetrahydronaphthyridinepentanamide integrin antagonists | ITGAV, ITGB3, ITGA4 | ITGAV 1/4885ITGB3 2/4885ITGB6 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.