Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066952 | 0.91 | KCNA5 (0.36) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL20557817 | 0.91 | KCNA5 (0.36) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL20557411 | 0.90 | POLB (0.36) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL22030701 | 0.90 | KCNA5 (0.33) | ACHEKCNA5ITGA4ITGB7POLB | |
| SCHEMBL4695546 | 0.90 | KCNA5 (0.34) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL4695543 | 0.90 | KCNA5 (0.34) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL4695537 | 0.90 | KCNA5 (0.34) | ACHEKCNA5POLBCYP3A4CYP2C9 | |
| SCHEMBL4130795 | 0.89 | POLB (0.35) | KCNA5POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4130799 | 0.89 | POLB (0.35) | KCNA5POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4133925 | 0.89 | ACHE (0.38) | ACHEKCNA5ALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110709081-B | Compounds and methods for treating bacterial infections | 恩塔西斯治疗公司 | 2023-09-22 | — | — | CN | disclosed |
| US-11046694-B2 | Compounds and methods for treating bacterial infections | ENTASIS THERAPEUTICS, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200165251-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | ENTASIS THERAPEUTICS, INC. | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046694-B2 | Compounds and methods for treating bacterial infections | MRPL21, CFTR, C5 | ACHE 1408/4885KCNA5 1510/4885ITGA4 2742/4885 |
| US-20200165251-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | MRPL21, CFTR, C5 | ACHE 1408/4885KCNA5 1510/4885ITGA4 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.