Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 5/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16185204 | 0.89 | ENPP2 (0.34) | CLPPENPP2KCNH2MAPK1DPP4 | |
| SCHEMBL16185213 | 0.86 | CLPP (0.33) | CLPPENPP2KCNH2MAPK1 | |
| SCHEMBL22030468 | 0.83 | TP53 (0.34) | CLPPENPP2KCNH2 | |
| SCHEMBL22030686 | 0.83 | TP53 (0.34) | CLPPENPP2KCNH2 | |
| SCHEMBL17547429 | 0.80 | CLPP (0.35) | CLPPKCNH2 | |
| SCHEMBL16185238 | 0.78 | CLPP (0.34) | CLPPKCNH2MAPK1 | |
| SCHEMBL16185260 | 0.76 | ERCC1 (0.36) | CLPPKCNH2MAPK1MAOB | |
| SCHEMBL22031051 | 0.74 | EGLN1 (0.35) | — | |
| SCHEMBL16185211 | 0.74 | CLPP (0.35) | CLPPENPP2KCNH2 | |
| SCHEMBL16185205 | 0.73 | ENPP2 (0.35) | CLPPENPP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986291-B1 | 4-PYRIDONE DERIVATIVE COMPOUNDS AND USES THEREOF AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-27 | — | — | EP | disclosed |