Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GLS | O94925 | 18/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484156 | 1.00 | HTT (0.63) | HTTGLSNAMPT | |
| SCHEMBL19920040 | 1.00 | HTT (0.63) | HTTGLSNAMPT | |
| SCHEMBL15042353 | 1.00 | HTT (0.63) | HTTGLSNAMPT | |
| SCHEMBL15480832 | 1.00 | HTT (0.63) | HTTGLSNAMPT | |
| SCHEMBL17083646 | 1.00 | HTT (0.63) | HTTGLSNAMPT | |
| SCHEMBL22031486 | 0.95 | HTT (0.61) | HTTGLS | |
| SCHEMBL21466309 | 0.95 | HTT (0.61) | HTTGLS | |
| SCHEMBL15782607 | 0.93 | GLS (0.64) | HTTGLS | |
| SCHEMBL14987275 | 0.93 | GLS (0.64) | HTTGLS | |
| SCHEMBL16379552 | 0.89 | HTT (0.62) | HTTGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165238-A1 | Heterocyclic Inhibitors of Glutaminase | CALITHERA BIOSCIENCES INC. | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165238-A1 | Heterocyclic Inhibitors of Glutaminase | GLS, GLS2, GLUL | HTT 301/4885GLS 1/4885NAMPT 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.