Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.74 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.74 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203285 | 1.00 | CHRNB4 (0.74) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL12386640 | 0.86 | CHRNB4 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL2199756 | 0.85 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL2199760 | 0.85 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4LTA4H | |
| SCHEMBL7615460 | 0.80 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7615451 | 0.80 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL18361619 | 0.78 | PDE4B (0.50) | CHRNB4CHRNA3 | |
| SCHEMBL13419311 | 0.78 | CHRNB2 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL17111303 | 0.77 | HTR2A (0.54) | — | |
| SCHEMBL23528211 | 0.77 | SLC6A2 (0.49) | CHRNB4CHRNA3LTA4HTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20100160352-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | HSP90AA1, TRAP1, HSP90AB1 | CHRNB4 4645/4885CHRNA3 3847/4885CHRNB2 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.