Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22033659 | 0.93 | LMNA (0.44) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL10536564 | 0.89 | LMNA (0.68) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL22077533 | 0.89 | LMNA (0.68) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL22033883 | 0.83 | LMNA (0.40) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL28609770 | 0.81 | MAPT (0.80) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL28617361 | 0.81 | MAPT (0.80) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL22033759 | 0.81 | LMNA (0.37) | LMNAMAPTMAPK1ALDH1A1BLM | |
| SCHEMBL28614977 | 0.81 | MAPT (0.80) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL28614879 | 0.81 | MAPT (0.80) | LMNAMAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL28605824 | 0.81 | MAPT (0.80) | LMNAMAPTMAPK1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891127-A1 | MODIFIED AMINE LIPIDS | Intellia Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020118041-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |