Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Riboflavin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.78 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 7/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.92 |
| ▸ | USP2 | O75604 | 4/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.92 |
| ▸ | HAT1 | O14929 | 4/20 | 0.92 |
| ▸ | RBBP7 | Q16576 | 4/20 | 0.92 |
| ▸ | HTT | P42858 | 4/20 | 0.92 |
| ▸ | RECQL | P46063 | 3/20 | 0.92 |
| ▸ | CASP7 | P55210 | 3/20 | 0.92 |
| ▸ | MAPT | P10636 | 3/20 | 0.92 |
| ▸ | CASP1 | P29466 | 2/20 | 0.92 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.92 |
| ▸ | TST | Q16762 | 2/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 1/20 | 0.92 |
| ▸ | HBB | P68871 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Riboflavin SCHEMBL826819 | 1.00 | MEN1 (0.92) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL50096 | 1.00 | MEN1 (0.92) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL20528621 | 0.99 | MEN1 (0.90) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL2241200 | 0.99 | MEN1 (0.90) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL27628044 | 0.99 | MEN1 (0.90) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL20474794 | 0.99 | MEN1 (0.90) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL27796272 | 0.98 | MEN1 (0.89) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL28875504 | 0.98 | MEN1 (0.89) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL7707 | 0.96 | MEN1 (1.00) | MEN1KMT2AUSP2KDM4EHAT1 | |
| Riboflavin SCHEMBL5899262 | 0.96 | MEN1 (1.00) | MEN1KMT2AUSP2KDM4EHAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914586-B1 | BIS(DIAZIRINE) DERIVATIVES AS PHOTO-CROSSSLINKER FOR TREATING CORNEAL ECTATIC DISORDERS | AVEDRO INC (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-3914586-A1 | BIS(DIAZIRINE) DERIVATIVES AS PHOTO-CROSSSLINKER FOR TREATING CORNEAL ECTATIC DISORDERS | Avedro Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3890741-A1 | COMPOUNDS AND COMPOSITIONS FOR EYE TREATMENTS | Avedro Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020154673-A1 | BIS(DIAZIRINE) DERIVATIVES AS PHOTO-CROSSSLINKER FOR TREATING CORNEAL ECTATIC DISORDERS | AVEDRO, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020117974-A1 | COMPOUNDS AND COMPOSITIONS FOR EYE TREATMENTS | AVEDRO, INC. (US) | 2020-06-11 | — | — | WO | disclosed |