Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.50 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829238 | 0.97 | MET (0.52) | METFLT3IRAK4KDRAXL | |
| SCHEMBL2202519 | 0.94 | MET (0.51) | METFLT3IRAK4KDRAXL | |
| SCHEMBL4557818 | 0.93 | MET (0.50) | METFLT3IRAK4KDRAXL | |
| SCHEMBL19347622 | 0.93 | MET (0.51) | METFLT3IRAK4KDRAXL | |
| SCHEMBL4473446 | 0.93 | MET (0.51) | METFLT3IRAK4KDRAXL | |
| SCHEMBL15062664 | 0.93 | MET (0.51) | METFLT3IRAK4KDR | |
| SCHEMBL3835477 | 0.92 | MET (0.49) | METFLT3IRAK4KDRAXL | |
| SCHEMBL3898054 | 0.92 | MET (0.50) | METFLT3IRAK4KDRAXL | |
| SCHEMBL3831025 | 0.92 | MET (0.51) | METFLT3IRAK4KDRAXL | |
| SCHEMBL3118425 | 0.92 | MET (0.51) | METFLT3IRAK4KDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392565-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |