Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829238 | 0.95 | MET (0.52) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL371610 | 0.93 | MET (0.47) | METFLT3KDREGFRFGFR1 | |
| SCHEMBL15519772 | 0.93 | MET (0.46) | METFLT3KDR | |
| SCHEMBL2204014 | 0.92 | MET (0.50) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL4557818 | 0.92 | MET (0.50) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL19347622 | 0.92 | MET (0.51) | METFLT3KDRIRAK4AXL | |
| SCHEMBL4473446 | 0.92 | MET (0.51) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL2202519 | 0.92 | MET (0.51) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL3898054 | 0.91 | MET (0.50) | METFLT3KDRIRAK4EGFR | |
| SCHEMBL3831025 | 0.91 | MET (0.51) | METFLT3KDRIRAK4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |