SCHEMBL22040144

SCHEMBL22040144

C[Si](C)(C)OC1(C#N)CC2(CC2)c2cc(Br)ccc21

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 13/20 0.33
APP P05067 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23891691 0.85
SCHEMBL22039715 0.80 BACE1 (0.31) BACE1
SCHEMBL768934 0.78 BACE1 (0.43) BACE1APP
SCHEMBL15919072 0.77 LMNA (0.36) BACE1APP
SCHEMBL1530577 0.77 BACE1 (0.35) BACE1APP
SCHEMBL15897036 0.75 BACE1 (0.37) BACE1APP
SCHEMBL17605283 0.72 BACE1 (0.32) BACE1
SCHEMBL17604835 0.68 PGR (0.34)
SCHEMBL768749 0.67
SCHEMBL16605598 0.66 BACE1 (0.35) BACE1APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3889138-B1 HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF HINOVA PHARMACEUTICALS INC (CN) 2024-11-20 EP disclosed
US-20220087996-A1 Histone acetylase p300 inhibitor and use thereof HINOVA PHARMACEUTICALS INC. (CN) 2022-03-24 US disclosed
EP-3889138-A1 HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF Hinova Pharmaceuticals Inc. (CN) 2021-10-06 EP disclosed
EP-3889138-A1 HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF Hinova Pharmaceuticals Inc. (CN) 2021-10-06 EP disclosed
WO-2020108500-A1 HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF 成都海创药业有限公司 2020-06-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220087996-A1 Histone acetylase p300 inhibitor and use thereof EP300, HDAC1, HDAC11 BACE1 829/4885APP 2274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.