SCHEMBL2204079

SCHEMBL2204079

C#Cc1ccccc1[SiH](C)C

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3283370 0.80 KDM4E (0.33) TSHR
SCHEMBL2173175 0.76 TSHR (0.30) TSHR
SCHEMBL6562670 0.76
SCHEMBL148575 0.73 TSHR (0.35) TSHR
SCHEMBL21936342 0.73 TSHR (0.35) TSHR
SCHEMBL28870 0.73 HDAC8 (0.36) HDAC8TSHR
SCHEMBL29549283 0.73 HDAC8 (0.36) HDAC8TSHR
SCHEMBL27731646 0.71 KCNH2 (0.42) HDAC8TSHR
SCHEMBL6564384 0.71
SCHEMBL28666492 0.71 NPC1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1964861-B1 ACETYLENE-BASED POLYMER NAT INST OF ADVANCED IND SCIEN (JP) 2012-10-17 EP disclosed
US-7977441-B2 Acetylene-based polymer NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2011-07-12 US disclosed
US-20090253872-A1 Acetylene-Based Polymer NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2009-10-08 US disclosed
EP-1964861-A1 ACETYLENE POLYMER National Institute of Advanced Industrial Science and Technology (JP) 2008-09-03 EP disclosed