Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | BRS3 | P32247 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22043531 | 0.86 | ALOX15 (0.67) | ALOX15HDAC8YAP1MAPTNPSR1 | |
| SCHEMBL23873669 | 0.85 | ALOX15 (0.38) | ALOX15HDAC8HCAR3BRS3 | |
| SCHEMBL23873680 | 0.84 | ALOX15 (0.71) | ALOX15MAPTNPSR1EPHX2BRS3 | |
| SCHEMBL22043546 | 0.82 | ALOX15 (0.67) | ALOX15HDAC8YAP1MAPTNPSR1 | |
| SCHEMBL32660002 | 0.78 | ALOX15 (0.54) | ALOX15HDAC8YAP1NPSR1HCAR3 | |
| SCHEMBL32660005 | 0.78 | ALOX15 (0.54) | ALOX15HDAC8YAP1NPSR1HCAR3 | |
| SCHEMBL20901213 | 0.77 | ALOX15 (0.45) | ALOX15BRS3 | |
| SCHEMBL16579940 | 0.72 | ALOX15 (0.55) | ALOX15HDAC8YAP1MAPTHCAR3 | |
| SCHEMBL22043870 | 0.72 | ALOX15 (0.52) | ALOX15HDAC8YAP1EPHX2 | |
| SCHEMBL15321170 | 0.71 | ALOX15 (0.70) | ALOX15HDAC8YAP1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020113028-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-06-04 | — | — | WO | disclosed |