Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22044045 | 0.92 | RAB9A (0.62) | MAPK1MAPK3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22044040 | 0.90 | ITK (0.62) | MAPK1MAPK3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22043984 | 0.82 | ITK (0.53) | MAPK1MAPK3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22044451 | 0.82 | ITK (0.53) | MAPK1MAPK3RAB9AITKMAPK8 | |
| SCHEMBL22043981 | 0.81 | FLT3 (0.55) | MAPK1RAB9AITKKDR | |
| SCHEMBL22044104 | 0.81 | ITK (0.49) | MAPK1MAPK3ALDH1A1ITKMAPK8 | |
| SCHEMBL21802612 | 0.80 | MAP2K4 (0.61) | MAPK1MAPK3RAB9ANPC1ALDH1A1 | |
| SCHEMBL29767728 | 0.80 | MAP2K4 (0.61) | MAPK1MAPK3RAB9ANPC1ALDH1A1 | |
| SCHEMBL22044530 | 0.80 | MAPK1 (0.60) | MAPK1MAPK3ITKMAPK8KDM4E | |
| SCHEMBL22044844 | 0.79 | ITK (0.48) | MAPK1MAPK3ITKMAPK8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172521-A1 | Five-Membered-Fused-Six-Membered Aza-Aromatic Ring Compound, Preparation Method Thereof, Pharmaceutical Composition And Application Thereof | Amcure Biosciences Pte. Ltd. (SG) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172521-A1 | Five-Membered-Fused-Six-Membered Aza-Aromatic Ring Compound, Preparation Method Thereof, Pharmaceutical Composition And Application Thereof | KRAS, NRAS, RASSF5 | MAPK1 3146/4885MAPK3 1726/4885RAB9A 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.