Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206952 | 0.88 | GSK3B (0.45) | FLT3GSK3AGSK3BPTGS2HTT | |
| SCHEMBL2204480 | 0.86 | IMPDH2 (0.40) | PTGS2HTTGAAKDM4EALDH1A1 | |
| SCHEMBL2204921 | 0.86 | MAP2 (0.45) | FLT3GSK3AGSK3BHTR2AHTR2C | |
| SCHEMBL2204248 | 0.85 | MEN1 (0.46) | HTR2AHTR2CHTR6HTTGAA | |
| SCHEMBL2206487 | 0.84 | GSK3A (0.44) | FLT3GSK3AGSK3BHTR2AHTR2C | |
| SCHEMBL21031865 | 0.78 | PTGDR2 (0.51) | FLT3GSK3AGSK3BHTR2AHTR2C | |
| SCHEMBL21031878 | 0.72 | PTGDR2 (0.45) | FLT3GSK3AGSK3BHTR2AHTR2C | |
| SCHEMBL27681973 | 0.70 | PTGS2 (0.59) | HTR2AHTR2CHTR7HTR6PTGS2 | |
| SCHEMBL13463019 | 0.70 | GAA (0.36) | HTTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL13440435 | 0.70 | CYP2C9 (0.48) | KDM4EALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981912-B2 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20100016389-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-7601749-B2 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH (US) | 2009-10-13 | — | — | US | disclosed |
| US-20090111867-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH (US) | 2009-04-30 | — | — | US | disclosed |
| US-7476667-B2 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080255100-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| US-7405215-B2 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | WYETH (US) | 2008-07-29 | — | — | US | disclosed |
| US-20060100425-A1 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | ATHERSYS, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100425-A1 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof | PTGDR2, TBXA2R, HCAR2 | FLT3 3892/4885GSK3A 2620/4885GSK3B 2899/4885 |
| US-20080255100-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | PTGDR2, TBXA2R, HCAR2 | FLT3 3892/4885GSK3A 2620/4885GSK3B 2899/4885 |
| US-20100016389-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | PTGDR2, TBXA2R, HCAR2 | FLT3 3892/4885GSK3A 2620/4885GSK3B 2899/4885 |
| US-20090111867-A1 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | PTGDR2, TBXA2R, HCAR2 | FLT3 3892/4885GSK3A 2620/4885GSK3B 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.