Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 1.00 |
| ▸ | HTR2A | P28223 | 11/20 | 1.00 |
| ▸ | HTR1A | P08908 | 9/20 | 1.00 |
| ▸ | ACHE | P22303 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22335855 | 0.90 | HTR2A (1.00) | DRD2HTR2AHTR1AACHEHTR6 | |
| SCHEMBL9994993 | 0.83 | DRD2 (0.70) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL792615 | 0.82 | DRD2 (0.70) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL31426759 | 0.81 | DRD2 (0.69) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL27137242 | 0.81 | DRD2 (0.69) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL1545611 | 0.80 | ACHE (0.93) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL31426754 | 0.80 | HTR2A (0.66) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL27138194 | 0.80 | HTR2A (0.66) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL31426708 | 0.78 | DRD2 (0.63) | DRD2HTR2AHTR1AACHESLC6A4 | |
| SCHEMBL27138774 | 0.78 | DRD2 (0.63) | DRD2HTR2AHTR1AACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828182-A1 | FUSED RING LACTAM DERIVATIVES | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | DRD2 430/4885HTR2A 947/4885HTR1A 362/4885 |
| US-10745401-B2 | Condensed lactam derivative | PSEN1, GRIN1, HDAC1 | DRD2 430/4885HTR2A 947/4885HTR1A 362/4885 |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | DRD2 430/4885HTR2A 947/4885HTR1A 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.