Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.78 |
| ▸ | RAB9A | P51151 | 13/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.78 |
| ▸ | HPGD | P15428 | 5/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.78 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.78 |
| ▸ | RELA | Q04206 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692412 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451127 | 0.80 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451353 | 0.76 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL24185813 | 0.75 | SMN1; SMN2 (0.87) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL10599193 | 0.75 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL12443363 | 0.75 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL19287154 | 0.75 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451198 | 0.75 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL12963200 | 0.74 | MAPT (0.74) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL29466151 | 0.74 | SMN1; SMN2 (0.74) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10953017-B2 | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such | SOUTHERN RESEARCH INSTITUTE (US) | 2021-03-23 | — | — | US | disclosed |
| US-20200171040-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | SOUTHERN RES INST (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200171040-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | NFKBIA, NFRKB, TFEB | NPC1 467/4885RAB9A 2402/4885SMN1; SMN2 29/4885 |
| US-10953017-B2 | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such | NFKBIA, NFRKB, TFEB | NPC1 467/4885RAB9A 2402/4885SMN1; SMN2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.