Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.64 |
| ▸ | RAB9A | P51151 | 11/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.64 |
| ▸ | RELA | Q04206 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.54 |
| ▸ | KCNK4 | Q9NYG8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451347 | 0.87 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451127 | 0.85 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL12692412 | 0.78 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL10599193 | 0.77 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451200 | 0.77 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL19287154 | 0.76 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451198 | 0.76 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL27451424 | 0.76 | MAPT (0.49) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL22057362 | 0.76 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL12963200 | 0.76 | MAPT (0.74) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145662-A1 | 2-SUBSTITUTED THIAZOLE AND BENZOTHIAZOLE COMPOSITIONS AND METHODS AS DUX4 INHIBITORS | ALTAY THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |