Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC2 | O75106 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.46 |
| ▸ | CASP6 | P55212 | 5/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108140 | 0.82 | AOC2 (0.69) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL27862485 | 0.81 | AOC2 (0.53) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL19608637 | 0.81 | AOC2 (0.57) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL28005159 | 0.79 | AOC2 (0.51) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL13689487 | 0.78 | AOC2 (0.50) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL594234 | 0.74 | AOC2 (0.64) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL29671334 | 0.74 | AOC2 (0.64) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL1388132 | 0.74 | AOC2 (0.58) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL20319187 | 0.73 | MAPT (0.68) | AOC2MAPTL3MBTL1CASP6DNMT1 | |
| SCHEMBL5813574 | 0.73 | AOC2 (0.62) | AOC2MAPTL3MBTL1CASP6DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172530-A1 | Small Molecule Sensitization of BAX Activation for Induction of Cell Death | DANA-FARBER CANCER INSTITUTE, INC. | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172530-A1 | Small Molecule Sensitization of BAX Activation for Induction of Cell Death | BAX, BAD, TMBIM6 | AOC2 4253/4885MAPT 4692/4885L3MBTL1 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.