Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14205653 | 0.80 | CHRM2 (0.37) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL10470951 | 0.72 | CHRM2 (0.65) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL3021293 | 0.70 | CHRM2 (0.50) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL9957501 | 0.70 | CA12 (0.32) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL9826154 | 0.68 | PER2 (0.32) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL20523332 | 0.68 | DPP4 (0.36) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL19142661 | 0.64 | CHRM2 (0.40) | CHRM2CHRM5CHRM1CHRM3CHRM4 | |
| SCHEMBL9827070 | 0.64 | CRBN (0.40) | ALDH1A1LMNA | |
| SCHEMBL9637899 | 0.64 | KMT2A (0.41) | CYP2D6ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5469516 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10821115-B2 | Compounds that inhibit Mcl-1 protein | AMGEN INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200171043-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10821115-B2 | Compounds that inhibit Mcl-1 protein | MCL1, BCL9, BCL2L1 | CHRM2 4881/4885CHRM5 4880/4885CHRM1 4872/4885 |
| US-20200171043-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | MCL1, BCL9, BCL2L1 | CHRM2 4881/4885CHRM5 4880/4885CHRM1 4872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.