Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.60 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | PPID | Q08752 | 2/20 | 0.49 |
| ▸ | PPIB | P23284 | 1/20 | 0.49 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | PPIG | Q13427 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.48 |
| ▸ | ITGAV | P06756 | 3/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12131750 | 0.90 | ERCC1 (0.70) | ERCC1ERCC4HDAC1MMECA1 | |
| SCHEMBL18232464 | 0.85 | TPSAB1 (0.61) | ERCC1ERCC4HDAC1CA1CA2 | |
| SCHEMBL13169668 | 0.85 | ERCC1 (0.60) | ERCC1ERCC4ALDH1A1CA1CA2 | |
| SCHEMBL24558042 | 0.85 | ERCC1 (0.64) | ERCC1ERCC4HDAC1ALDH1A1KMT2A | |
| SCHEMBL18887748 | 0.83 | ERCC1 (0.67) | ERCC1ERCC4HDAC1KMT2ATPSAB1 | |
| SCHEMBL22060015 | 0.83 | ERCC1 (0.62) | ERCC1ERCC4EPHX2HDAC1MME | |
| SCHEMBL12757443 | 0.83 | KMT2A (0.63) | ERCC1ERCC4ALDH1A1KMT2AMEN1 | |
| SCHEMBL12134066 | 0.83 | ERCC1 (0.62) | ERCC1ERCC4HDAC1ALDH1A1MME | |
| SCHEMBL13848262 | 0.82 | ERCC1 (0.57) | ERCC1ERCC4EPHX2HDAC1CA1 | |
| SCHEMBL21781976 | 0.82 | ITGB1 (0.51) | ERCC1ERCC4EPHX2ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129790-B2 | Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates | NORTHEASTERN UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN (DE) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | NR1H4, NR1H3, NR1H2 | ERCC1 2685/4885ERCC4 1558/4885EPHX2 6/4885 |
| US-11129790-B2 | Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates | GLUL, QPCT, DNPEP | ERCC1 1634/4885ERCC4 2635/4885EPHX2 1840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.