Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 11/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 10/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30662619 | 0.99 | EGFR (0.46) | EGFRTTBK1TTBK2MKNK1AURKA | |
| SCHEMBL22060801 | 0.98 | EGFR (0.47) | EGFRTTBK1TTBK2MKNK1AURKA | |
| SCHEMBL22061117 | 0.97 | EGFR (0.46) | EGFRTTBK1TTBK2MKNK1AURKA | |
| Hydrochloric Acid SCHEMBL30662594 | 0.96 | MKNK1 (0.45) | EGFRTTBK1TTBK2MKNK1AURKA | |
| SCHEMBL22061565 | 0.92 | TTBK1 (0.45) | EGFRTTBK1TTBK2MKNK1AURKA | |
| SCHEMBL22061122 | 0.80 | MKNK1 (0.54) | EGFRTTBK1TTBK2MKNK1BRAF | |
| Hydrochloric Acid SCHEMBL30662605 | 0.79 | MKNK1 (0.53) | EGFRTTBK1TTBK2MKNK1BRAF | |
| SCHEMBL22061384 | 0.78 | MKNK1 (0.54) | EGFRTTBK1TTBK2MKNK1 | |
| Hydrochloric Acid SCHEMBL30662572 | 0.77 | MKNK1 (0.53) | EGFRTTBK1TTBK2MKNK1 | |
| SCHEMBL22061389 | 0.76 | MKNK1 (0.43) | EGFRTTBK1TTBK2MKNK1TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108619-A1 | MNK INHIBITOR | 上海迪诺医药科技有限公司 | 2020-06-04 | — | — | WO | disclosed |
| US-9428750-B2 | Oligomeric compounds comprising tricyclic nucleosides and methods for their use | IONIS PHARMACEUTICALS, INC. (US) | 2016-08-30 | — | — | US | disclosed |