Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.59 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.59 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.59 |
| ▸ | NSD2 | O96028 | 4/20 | 0.59 |
| ▸ | PCMT1 | P22061 | 2/20 | 0.59 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.59 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | RNMT | O43148 | 1/20 | 0.59 |
| ▸ | INMT | O95050 | 1/20 | 0.59 |
| ▸ | NNMT | P40261 | 1/20 | 0.59 |
| ▸ | TPMT | P51580 | 1/20 | 0.59 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.59 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.59 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.59 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.59 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25634790 | 1.00 | EHMT1 (0.59) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL19760484 | 1.00 | EHMT1 (0.59) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL22110013 | 1.00 | EHMT1 (0.59) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL22062402 | 0.90 | DOT1L (0.60) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL22062505 | 0.85 | DOT1L (0.74) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL19760477 | 0.85 | DOT1L (0.74) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL22062506 | 0.85 | DOT1L (0.74) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL25634757 | 0.83 | DOT1L (0.69) | EHMT1EHMT2DOT1LNSD2PCMT1 | |
| SCHEMBL13986299 | 0.81 | DPP4 (0.74) | EHMT1EHMT2DOT1LPRMT5DPP4 | |
| SCHEMBL173151 | 0.81 | DPP4 (0.74) | EHMT1EHMT2DOT1LPRMT5DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676499-B2 | 3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA | NOVARTIS AG (CH) | 2020-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10676499-B2 | 3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA | RNGTT, NSUN3, NSUN2 | EHMT1 1157/4885EHMT2 908/4885DOT1L 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.