Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18314661 | 0.79 | BACE1 (0.50) | BACE1HPGDHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL22062891 | 0.76 | NOS2 (0.38) | BACE1NOS3NOS1NOS2POLB | |
| SCHEMBL18310643 | 0.74 | BACE1 (0.46) | BACE1HPGDHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL21733359 | 0.74 | HSP90AA1 (0.35) | BACE1HSP90AA1HSP90AB1NOS3NOS1 | |
| SCHEMBL29295852 | 0.73 | NOS3 (0.34) | NOS3NOS1NOS2POLB | |
| SCHEMBL15429603 | 0.73 | KDM4E (0.42) | BACE1HPGDHSD17B10KDM4EALDH1A1 | |
| SCHEMBL22063480 | 0.73 | BACE1 (0.41) | BACE1HPGDHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL26707264 | 0.70 | BACE1 (0.42) | BACE1HPGDHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL2478082 | 0.69 | BACE1 (0.44) | BACE1HPGDHSD17B10KDM4EALDH1A1 | |
| SCHEMBL2482824 | 0.69 | BACE1 (0.44) | BACE1HPGDHSD17B10CFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236068-B2 | Fused ring compounds | GENENTECH, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210230142-A9 | FUSED RING COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-07-29 | — | — | US | disclosed |
| US-20200181118-A1 | FUSED RING COMPOUNDS | GENENTECH INC (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230142-A9 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | BACE1 2019/4885HPGD 2966/4885HSD17B10 3025/4885 |
| US-20200181118-A1 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | BACE1 2019/4885HPGD 2966/4885HSD17B10 3025/4885 |
| US-11236068-B2 | Fused ring compounds | KRAS, NRAS, HRAS | BACE1 2019/4885HPGD 2966/4885HSD17B10 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.