Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 9/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703126 | 0.83 | ADAMTS5 (0.50) | ADAM17ADAMTS5PDE4BPDE7AQDPR | |
| SCHEMBL22063189 | 0.80 | ADAM17 (0.64) | ADAM17ADAMTS5QDPR | |
| SCHEMBL19703085 | 0.79 | ADAM17 (0.49) | ADAM17ADAMTS5PDE4B | |
| SCHEMBL19703141 | 0.76 | ADAM17 (0.55) | ADAM17ADAMTS5PDE4B | |
| SCHEMBL22063674 | 0.73 | PDE4B (0.44) | ADAM17PDE4B | |
| SCHEMBL22063179 | 0.72 | PDE4B (0.56) | PDE4BQDPR | |
| SCHEMBL22022934 | 0.72 | ADAM17 (0.47) | ADAM17ADAMTS5QDPR | |
| SCHEMBL28818478 | 0.69 | HTR2A (0.55) | PDE4BQDPR | |
| SCHEMBL11337779 | 0.69 | PDE4B (0.42) | PDE4BPDE7AGAAQDPR | |
| SCHEMBL22063174 | 0.68 | ADAM17 (0.63) | ADAM17ADAMTS5QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |