Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.66 |
| ▸ | ADAMTS5 | Q9UNA0 | 10/20 | 0.51 |
| ▸ | QDPR | P09417 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22063174 | 0.88 | ADAM17 (0.63) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22063686 | 0.87 | ADAM17 (0.64) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22063189 | 0.87 | ADAM17 (0.64) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22063188 | 0.86 | ADAMTS5 (0.64) | ADAM17ADAMTS5QDPR | |
| SCHEMBL19703139 | 0.84 | ADAM17 (0.57) | ADAM17ADAMTS5 | |
| SCHEMBL22063183 | 0.81 | ADAM17 (0.61) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22063780 | 0.81 | ADAM17 (0.63) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22063172 | 0.81 | ADAM17 (0.62) | ADAM17ADAMTS5QDPR | |
| SCHEMBL22892289 | 0.81 | ALK (0.48) | ADAM17ADAMTS5 | |
| SCHEMBL19691677 | 0.80 | ADAM17 (1.00) | ADAM17ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |