Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 13/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19702754 | 0.91 | ADAMTS5 (0.51) | ADAMTS5KCNH2HRH3CCR1PRMT5 | |
| SCHEMBL21693588 | 0.89 | ADAMTS5 (0.49) | ADAMTS5KCNH2HRH3CCR1PRMT5 | |
| SCHEMBL22063769 | 0.80 | CCR1 (0.54) | ADAMTS5KCNH2CCR1 | |
| SCHEMBL24340329 | 0.79 | ADAMTS5 (0.61) | ADAMTS5KCNH2HRH3CCR1 | |
| SCHEMBL22063775 | 0.78 | ADAMTS5 (0.55) | ADAMTS5KCNH2CCR1 | |
| SCHEMBL22062940 | 0.78 | ADAMTS5 (0.55) | ADAMTS5KCNH2CCR1 | |
| SCHEMBL21424854 | 0.78 | ADAMTS5 (0.51) | ADAMTS5CCR1 | |
| SCHEMBL21424885 | 0.78 | ADAMTS5 (0.53) | ADAMTS5CCR1 | |
| SCHEMBL13588778 | 0.75 | KCNH2 (0.64) | ADAMTS5KCNH2HRH3CCR1NAMPT | |
| SCHEMBL4029855 | 0.74 | PRMT5 (0.58) | KCNH2HRH3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |