Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 19/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19702754 | 0.89 | ADAMTS5 (0.51) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL22062940 | 0.87 | ADAMTS5 (0.55) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL22063775 | 0.81 | ADAMTS5 (0.55) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL22063764 | 0.80 | ADAMTS5 (0.51) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL21424866 | 0.78 | ADAMTS5 (0.51) | CCR1ADAMTS5 | |
| SCHEMBL21424854 | 0.78 | ADAMTS5 (0.51) | CCR1ADAMTS5 | |
| SCHEMBL21693588 | 0.78 | ADAMTS5 (0.49) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL19652150 | 0.76 | CCR1 (0.70) | CCR1ADAMTS5KCNH2 | |
| SCHEMBL23901417 | 0.76 | ADAMTS5 (0.50) | ADAMTS5 | |
| SCHEMBL22063187 | 0.74 | ADAM17 (0.46) | ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |