Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 12/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 11/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 8/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22065200 | 0.84 | DDR2 (0.60) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL22025455 | 0.81 | DDR2 (0.65) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL2976022 | 0.81 | KIT (0.68) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL28971866 | 0.79 | ABL1 (0.62) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL2965773 | 0.79 | KIT (0.69) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL30080652 | 0.79 | KIT (0.69) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL22024682 | 0.79 | BRAF (0.82) | BRAFEGFRKIT | |
| SCHEMBL22065199 | 0.78 | DDR1 (0.63) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL13220188 | 0.78 | DDR2 (0.71) | DDR2DDR1NTRK1NTRK3NTRK2 | |
| SCHEMBL22024687 | 0.77 | BRAF (0.76) | BRAFEGFRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |