Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | APEX1 | P27695 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 7/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.53 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.53 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.53 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.53 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.53 |
| ▸ | AGPS | O00116 | 2/20 | 0.53 |
| ▸ | MYO1F | O00160 | 2/20 | 0.53 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.53 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.53 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22066412 | 0.94 | POLB (0.57) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22066322 | 0.93 | LCK (0.54) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22065355 | 0.89 | LCK (0.54) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22066328 | 0.87 | POLB (0.55) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22066074 | 0.82 | BRAF (0.61) | APEX1LCKMAPK14BRAFKDR | |
| SCHEMBL22025326 | 0.81 | POLB (0.58) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22066484 | 0.80 | MAPK14 (0.68) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL22024567 | 0.80 | BRAF (0.81) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL17131157 | 0.76 | MAPK14 (0.72) | POLBAPEX1MAPTLCKMAPK14 | |
| SCHEMBL24532063 | 0.74 | POLB (0.67) | POLBAPEX1MAPTLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |