Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.52 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.48 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.48 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24532071 | 0.82 | POLB (0.68) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL22024705 | 0.81 | PIKFYVE (0.75) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL22025503 | 0.80 | POLB (0.63) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL22065428 | 0.80 | POLB (0.58) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL5023651 | 0.79 | POLB (0.68) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL24532063 | 0.78 | POLB (0.67) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL22024864 | 0.75 | PIKFYVE (0.85) | POLBBRAFKDRTEKCSF1R | |
| SCHEMBL22024643 | 0.74 | PIKFYVE (0.74) | POLBMAPTAPEX1MAPK14LCK | |
| SCHEMBL22024821 | 0.74 | PIKFYVE (0.62) | POLBMAPTBRAFKDRTEK | |
| SCHEMBL22024557 | 0.73 | PIKFYVE (0.61) | POLBMAPK14LCKBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |