Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 6/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | EYA2 | O00167 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28317228 | 0.89 | ALDH1A1 (0.53) | HSPB1EPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22069742 | 0.87 | HSPB1 (0.60) | HSPB1EPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL2529627 | 0.86 | ALDH1A1 (0.67) | EPAS1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3845633 | 0.84 | MEN1 (0.67) | HSPB1EPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22069708 | 0.84 | HSPB1 (0.68) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4082910 | 0.84 | HSPB1 (0.68) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL124556 | 0.82 | TBXA2R (0.54) | EPAS1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL22069594 | 0.82 | HSPB1 (0.61) | HSPB1EPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL14965155 | 0.81 | HSPB1 (0.73) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2035696 | 0.81 | HSPB1 (0.53) | HSPB1MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |